Simpson Fiona, Kerr Markus C, Wicking Carol
The University of Queensland, Institute for Molecular Bioscience, Qld, Australia.
Mech Dev. 2009 May-Jun;126(5-6):279-88. doi: 10.1016/j.mod.2009.01.007. Epub 2009 Feb 4.
Embryogenesis is mediated by a relatively small number of developmental signaling pathways, and the morphogens, receptors and transcription factors integral to these cascades are considered the master regulators of development. However, superimposed on this is an additional layer of control by complex intracellular trafficking networks. The importance of trafficking in controlling the processes of morphogenesis and development is highlighted by recent data regarding the transport and localisation of the morphogen sonic hedgehog (Shh) and the machinery that leads to its secretion, modification, cellular internalisation and signal transduction. Here we review the regulation of hedgehog signaling by intracellular trafficking, including the role of the primary cilium and lipids in mediating pathway activity.
胚胎发育由相对少数的发育信号通路介导，这些级联反应中不可或缺的形态发生素、受体和转录因子被视为发育的主要调节因子。然而，在此基础上还有复杂的细胞内运输网络进行额外的控制。形态发生素音猬因子（Shh）的运输和定位以及导致其分泌、修饰、细胞内化和信号转导的机制的最新数据突出了运输在控制形态发生和发育过程中的重要性。在这里，我们综述细胞内运输对刺猬信号通路的调节，包括初级纤毛和脂质在介导信号通路活性中的作用。
