Zheng Jiahao, Huo Desheng, Wang Kaizhong, Zhao Hui
Bethune First Clinical Medical College, Jilin University, Changchun, Jilin, China.
Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
Int J Dev Neurosci. 2025;85(6):e70051. doi: 10.1002/jdn.70051.
Neural tube defects (NTDs), such as anencephaly and spina bifida, are prevalent congenital anomalies of the central nervous system. These defects can give rise to severe lifelong disabilities and incur substantial healthcare expenses for the affected individuals. The occurrence of NTDs is caused by multiple factors, including molecular regulatory mechanisms and environmental factors. This article comprehensively reviews the underlying mechanisms of three crucial signalling pathways associated with neural tube development: the Wnt/Planar Cell Polarity (PCP) signalling pathway, the Sonic Hedgehog signalling pathway and the Notch signalling pathway, and, on this basis, delves into the potential molecular therapeutic strategies for NTDs. This review is of great significance for comprehensively elucidating the molecular causes of NTDs and expanding prevention and treatment strategies for related congenital anomalies.
神经管缺陷（NTDs），如无脑儿和脊柱裂，是中枢神经系统常见的先天性异常。这些缺陷可导致严重的终身残疾，并给受影响个体带来巨额医疗费用。NTDs的发生是由多种因素引起的，包括分子调控机制和环境因素。本文全面综述了与神经管发育相关的三条关键信号通路：Wnt/平面细胞极性（PCP）信号通路、音猬因子信号通路和Notch信号通路的潜在机制，并在此基础上深入探讨了NTDs的潜在分子治疗策略。本综述对于全面阐明NTDs的分子病因以及拓展相关先天性异常的防治策略具有重要意义。
