Rodrigues Alex G, Soares Danusa D, Marubayashi Umeko, Coimbra Cândido Celso
Department of Physiology and Biophysics, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Neuroreport. 2009 May 27;20(8):804-8. doi: 10.1097/WNR.0b013e32832b8c90.
To investigate the influence of the central cholinergic system on thermoregulation and brain serotonin concentration during exercise; 2 microl of physostigmine (5x10 M) or saline solution was injected into the lateral cerebral ventricle of running rats. At fatigue, brains were quickly removed and serotonin and 5-hydroxyindoleacetic acid were measured in the preoptic area, hypothalamus, frontal cortex, and hippocampus. Physostigmine injection attenuated hyperthermia and exercise-induced heat storage that was closely related to the serotonin content in the preoptic area. Physostigmine treatment also increased the heat dissipation by decreasing core temperature threshold for vasodilation. In conclusion, our data indicated that stimulation of the central cholinergic system promotes heat dissipation in running rats that is related to decreased serotonin content in the preoptic area.
为研究中枢胆碱能系统在运动过程中对体温调节及脑血清素浓度的影响；将2微升毒扁豆碱（5×10⁻⁶ M）或生理盐水注入正在奔跑的大鼠侧脑室。在疲劳时，迅速取出大脑，测定视前区、下丘脑、额叶皮质和海马体中的血清素和5-羟吲哚乙酸。注射毒扁豆碱可减轻高热和运动诱导的热蓄积，这与视前区血清素含量密切相关。毒扁豆碱处理还通过降低血管舒张的核心温度阈值来增加散热。总之，我们的数据表明，刺激中枢胆碱能系统可促进奔跑大鼠的散热，这与视前区血清素含量降低有关。
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