Hooper Lora V
Department of Immunology, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
Nat Rev Microbiol. 2009 May;7(5):367-74. doi: 10.1038/nrmicro2114.
The mammalian intestine is home to dense and complex indigenous bacterial communities. Most of these bacteria establish beneficial symbiotic relationships with their hosts, making important contributions to host metabolism and digestive efficiency. The vast numbers of intestinal bacteria and their proximity to host tissues raise the question of how symbiotic host-bacterial relationships are established without eliciting potentially harmful immune responses. In light of the varied ways in which pathogenic bacteria manipulate host immunity, this Opinion article explores the role of immune suppression, subversion and evasion in the establishment of symbiotic host-bacterial associations.
哺乳动物的肠道是密集且复杂的本土细菌群落的栖息地。这些细菌中的大多数与宿主建立了有益的共生关系，对宿主代谢和消化效率做出了重要贡献。大量的肠道细菌及其与宿主组织的紧密 proximity 引发了一个问题，即共生的宿主 - 细菌关系是如何在不引发潜在有害免疫反应的情况下建立的。鉴于病原菌操纵宿主免疫的多种方式，这篇观点文章探讨了免疫抑制、颠覆和逃避在共生宿主 - 细菌关联建立中的作用。 （注：proximity 原英文拼写有误，正确拼写为 proximity，意为“接近，临近” ）
