Kéri Szabolcs, Kelemen Oguz, Benedek György
Semmelweis University, Department of Psychiatry and Psychotherapy, Budapest, Hungary.
Cogn Neuropsychiatry. 2009 Mar;14(2):77-86. doi: 10.1080/13546800902757936.
Previous studies indicated impaired perceptual organisation in schizophrenia. This study investigated lateral connection and attentional modulation in early visual cortex of schizophrenia patients.
Contrast threshold was measured for a central Gabor patch, flanked with orthogonal and collinear Gabor patches. In the attended condition, participants performed a concurrent vernier task by determining the spatial offset of the flankers.
The controls (n=25) had lower contrast thresholds in the collinear condition than in the orthogonal condition, whereas the schizophrenia patients (n=43) did not benefit from the presence of collinear flankers. This deficit was not ameliorated by attentional modulation. Antipsychotic medication did not affect the performance.
These results suggest that lateral connections are impaired in early visual cortex of schizophrenia patients. This deficit cannot be restored by top-down attentional modulation of target-flanker interactions.
先前的研究表明精神分裂症患者存在感知组织受损的情况。本研究调查了精神分裂症患者早期视觉皮层中的侧向连接和注意力调节。
测量中央Gabor斑块以及两侧正交和共线Gabor斑块的对比度阈值。在注意力集中的条件下，参与者通过确定侧翼的空间偏移来执行并发游标任务。
对照组（n = 25）在共线条件下的对比度阈值低于正交条件，而精神分裂症患者（n = 43）并未从共线侧翼的存在中受益。这种缺陷不会因注意力调节而改善。抗精神病药物治疗对表现没有影响。
这些结果表明精神分裂症患者早期视觉皮层中的侧向连接受损。这种缺陷无法通过对目标 - 侧翼相互作用的自上而下的注意力调节来恢复。
