Mulholland Selamawit, Chang Anne B
Queensland Respiratory Centre, Royal Children's Hospital, Herston, Queensland, Australia.
Cochrane Database Syst Rev. 2009 Apr 15;2009(2):CD007523. doi: 10.1002/14651858.CD007523.pub2.
Chronic non-specific cough is a chronic, dry cough of in the absence of identifiable respiratory disease or known aetiology. Although it is usually not reflective of an underlying severe illness, it does cause significant morbidity, and as such relief from it is often sought. The use of honey and lozenges to soothe upper respiratory tract irritation is common, inexpensive, and potentially more effective in treating the symptoms than pharmacological interventions.
To evaluate the efficacy of honey and/or lozenges in the management of children with chronic non-specific cough.
The Cochrane Airways Group searched the Cochrane Register of Controlled Trials (CENTRAL), MEDLINE, OLDMEDLINE, and EMBASE databases in October 2008.
All randomised controlled trials comparing honey or lozenges with a placebo in treating children with chronic non-specific cough.
The results of the searches were assessed according to the pre-determined criteria. None of the trials identified by the searches were eligible for inclusion, leaving no data available for analysis in this review.
The search did not provide any applicable randomised controlled trials that investigated the efficacy of honey and lozenges in treating children with non-specific chronic cough. Data from acute studies suggest a potential role for honey in relieving cough, but whether this is applicable to chronic cough is unknown.
AUTHORS' CONCLUSIONS: Clinically, this review was unable to provide any justifiable recommendation for or against honey and/or lozenges due to the lack of evidence. The absence of applicable studies highlights the need for further research into the area of treating children with chronic non-specific coughs with honey and/or lozenges. These treatments are not recommended when managing very young children (as lozenges are a potential choking hazard, and honey may cause infant botulism in children under 1 year of age).
慢性非特异性咳嗽是一种无明确可识别的呼吸道疾病或已知病因的慢性干咳。尽管它通常不反映潜在的严重疾病,但确实会导致明显的发病率,因此人们常常寻求缓解方法。使用蜂蜜和含片来缓解上呼吸道刺激很常见,价格低廉,而且在治疗症状方面可能比药物干预更有效。
评估蜂蜜和/或含片对慢性非特异性咳嗽儿童的治疗效果。
Cochrane气道组于2008年10月检索了Cochrane对照试验注册库(CENTRAL)、MEDLINE、OLDMEDLINE和EMBASE数据库。
所有比较蜂蜜或含片与安慰剂治疗慢性非特异性咳嗽儿童的随机对照试验。
根据预先确定的标准评估检索结果。检索到的试验均不符合纳入标准,因此本综述没有可供分析的数据。
检索未提供任何研究蜂蜜和含片治疗非特异性慢性咳嗽儿童疗效的适用随机对照试验。急性研究的数据表明蜂蜜在缓解咳嗽方面可能有作用,但这是否适用于慢性咳嗽尚不清楚。
在临床上,由于缺乏证据,本综述无法对蜂蜜和/或含片的使用提供任何合理的支持或反对建议。缺乏适用的研究突出了对使用蜂蜜和/或含片治疗慢性非特异性咳嗽儿童领域进行进一步研究的必要性。在管理非常年幼的儿童时不推荐使用这些治疗方法(因为含片有潜在的窒息风险,蜂蜜可能会导致1岁以下儿童患婴儿肉毒杆菌中毒)。