气体置换玻璃体作为细菌性眼内炎的一种治疗方式。

Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis.

作者信息

Mansour A M, Ferguson E, Lucia H, Rajashekhar M, Li H, Margo T

机构信息

Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.

出版信息

Graefes Arch Clin Exp Ophthalmol. 1991;229(5):468-72. doi: 10.1007/BF00166312.

DOI:10.1007/BF00166312

PMID:1937081

Abstract

We investigated vitreous replacement by long-lasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P less than 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

摘要

我们对19只家兔进行了研究，将其随机分为两组，一组9只接受玻璃体切除术，另一组10只接受玻璃体切除术后用20%全氟丙烷 - 80%空气混合物替代玻璃体，以此来研究长效气体替代玻璃体在严重金黄色葡萄球菌性眼内炎治疗中的作用。两组均接受全身抗生素治疗，眼内抗生素水平相当。临床和组织病理学检查显示，充气眼的炎症比未充气眼轻（P<0.01）。气体替代玻璃体是玻璃体切除术的一种有效辅助手段，它可消除培养基、预防玻璃体脓肿形成、便于眼底观察并延缓视网膜脱离的发生。