Amuasi J H, Ferri P, Grossi A, Vannucchi L, Vannucchi A M, Ferrini P R
Divisione di Ematologia, USL 10/D, Firenze, Italy.
Haematologica. 1991 Mar-Apr;76(2):104-8.
Twenty-five thrombocytopenic patients underwent quantitative in vivo platelet kinetic studies using a scintillation camera and a computer-assisted imaging system. They fulfilled the criteria for chronic immune thrombocytopenia, and the object of the study was to evaluate platelet sequestration and destruction in the spleen. In this sense, the differences in the distribution of the radiolabelled platelets in the spleen and the liver, as well as the differences in the platelet mean life span (MLS) as computed by different methods were assessed. Serial images of the spleen pool, liver and heart were taken after reinjection of In-111-oxine labelled autologous platelets.
The spleen/liver ratio proved to be a more reliable index in indicating the splenectomy outcome that the Z index (see text). Platelet survival curves were analyzed using four mathematical models, and it was found that MLS estimation is model dependent. Thus, it seem advisable to apply at least two different methods when analyzing experimental data.
25例血小板减少症患者使用闪烁相机和计算机辅助成像系统进行了体内血小板定量动力学研究。他们符合慢性免疫性血小板减少症的标准，本研究的目的是评估脾脏中血小板的扣押和破坏情况。从这个意义上讲，评估了放射性标记血小板在脾脏和肝脏中的分布差异，以及通过不同方法计算的血小板平均寿命（MLS）差异。在重新注射铟-111-奥克辛标记的自体血小板后，拍摄脾脏血池、肝脏和心脏的系列图像。
脾脏/肝脏比值被证明是比Z指数（见正文）更可靠的脾切除结果指标。使用四种数学模型分析血小板存活曲线，发现MLS估计依赖于模型。因此，在分析实验数据时，似乎建议至少应用两种不同的方法。
