Kotzé H F, Heyns A D, Lötter M G, Pieters H, Roodt J P, Sweetlove M A, Badenhorst P N
MRC Blood Platelet Research Unit, University of the Orange Free State, Bloemfontein, South Africa.
J Nucl Med. 1991 Jan;32(1):62-6.
The effect of the chelates oxine and tropolone, used to label platelets, on the kinetics of indium-111-(111In) labeled platelets was studied in twelve normal human subjects. Autologous platelets were labeled either in saline with 111In-oxine or in plasma with 111In-tropolone. Mean platelet lifespan was estimated by fitting the disappearance curve of platelets from the circulation to the multiple hit and other mathematical models. The in vivo distribution of platelets was quantitatively imaged with a scintillation camera. The in vivo recovery of 111In-oxine and 111In-tropolone did not differ, and the mean platelet lifespan was also similar (111In-oxine: 230 +/- 29 hr; 111In-tropolone: 226 +/- 13 hr). At equilibrium (90 min after reinjection of labeled platelets) and at the end of platelet lifespan, 111In-oxine and 111In-tropolone radioactivities in the spleen and liver were similar. These results demonstrate that the results of kinetics measured with 111In-oxine or 111In-tropolone do not differ significantly.
在12名正常人体受试者中研究了用于标记血小板的螯合物8-羟基喹啉和托酚酮对铟-111（111In）标记血小板动力学的影响。自体血小板分别在含111In-8-羟基喹啉的盐溶液中或含111In-托酚酮的血浆中进行标记。通过将循环中血小板的消失曲线与多次打击模型及其他数学模型拟合来估计平均血小板寿命。用闪烁相机对血小板的体内分布进行定量成像。111In-8-羟基喹啉和111In-托酚酮的体内回收率无差异，平均血小板寿命也相似（111In-8-羟基喹啉：230±29小时；111In-托酚酮：226±13小时）。在平衡状态（重新注入标记血小板后90分钟）以及血小板寿命结束时，脾脏和肝脏中111In-8-羟基喹啉和111In-托酚酮的放射性相似。这些结果表明，用111In-8-羟基喹啉或111In-托酚酮测量的动力学结果无显著差异。
