Gliklich Richard, Wilson Jerome
Outcome Sciences, Inc, Cambridge, MA, USA.
J Oral Maxillofac Surg. 2009 May;67(5 Suppl):71-4. doi: 10.1016/j.joms.2009.01.005.
Little is known about the epidemiology of osteonecrosis of the jaws. To date, no population-based studies have rigorously evaluated risk factors, treatment factors, or outcomes. We aimed to perform such a study.
We reviewed the literature for epidemiologic studies on osteonecrosis of the jaws.
Current epidemiologic information is generally derived from anecdotal reports or case series from small institutions. Estimates that have been provided in some reports have questionable validity because of a lack of standardized case definitions, clearly defined source populations, and clear methods for obtaining (or confirming) full reporting. Population-based prospective registries are capable of answering and informing several of the outstanding questions about bisphosphonate-related osteonecrosis of the jaws/osteonecrosis of the jaws.
A population-based registry that collects systematic information on patient characteristics, treatments, and outcomes is essential to filling the gaps in our knowledge and understanding of bisphosphonate-related osteonecrosis of the jaws.
关于颌骨骨坏死的流行病学情况，人们了解甚少。迄今为止，尚无基于人群的研究对风险因素、治疗因素或治疗结果进行严格评估。我们旨在开展这样一项研究。
我们检索了关于颌骨骨坏死的流行病学研究文献。
当前的流行病学信息通常来源于小型机构的轶事报道或病例系列。由于缺乏标准化的病例定义、明确界定的源人群以及获取（或确认）完整报告的明确方法，一些报告中给出的估计值的有效性存疑。基于人群的前瞻性登记系统能够回答并为一些有关双膦酸盐相关颌骨骨坏死/颌骨骨坏死的悬而未决的问题提供信息。
一个收集有关患者特征、治疗方法和治疗结果的系统信息的基于人群的登记系统对于填补我们在双膦酸盐相关颌骨骨坏死知识和理解方面的空白至关重要。
