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中欧人群中基于云的双膦酸盐相关颌骨坏死多中心数据收集与流行病学分析

Cloud-Based Multicenter Data Collection and Epidemiologic Analysis of Bisphosphonate-Related Osteonecrosis of the Jaws in a Central European Population.

作者信息

Vereb Tamás, Boda Krisztina, Czakó László, Vaszilkó Mihály, Fülöp Gábor, Klenk Gusztáv, Janovszky Ágnes, Oberna Ferenc, Piffkó József, Seres László

机构信息

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary.

Department of Medical Physics and Informatics, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary.

出版信息

J Clin Med. 2020 Feb 5;9(2):426. doi: 10.3390/jcm9020426.

DOI:10.3390/jcm9020426
PMID:32033299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7073980/
Abstract

: Bisphosphonate-related osteonecrosis of the jaws is considered to be a rare but severe complication of bisphosphonate therapy. To understand this condition better, data collection is essential. Although the number of scientific papers about this subject is large, to date only a few multicenter reports have been published. : We present a novel cloud-based data collection system for the evaluation of the risk factors of bisphosphonate-related osteonecrosis of the jaws. Web-based questionnaire and database have been set up and made available to voluntary researchers and clinicians in oral and maxillofacial surgery in Hungary and Slovakia. : To date, fifteen colleagues from eight maxillofacial units have joined the study. Data of 180 patients have been recorded. Collected data were statistically analysed and evaluated from an epidemiological point of view. : Authors consider cloud-based multicenter data collection a useful tool that allows for real-time collaboration between users, facilitates fast data entry and analysis, and thus considerably contributes to widening our knowledge of bisphosphonate-related osteonecrosis of the jaws.

摘要

双膦酸盐相关颌骨坏死被认为是双膦酸盐治疗罕见但严重的并发症。为了更好地了解这种情况,数据收集至关重要。尽管关于该主题的科学论文数量众多,但迄今为止仅发表了少数多中心报告。:我们提出了一种基于云的数据收集系统,用于评估双膦酸盐相关颌骨坏死的危险因素。基于网络的问卷和数据库已经建立,并提供给匈牙利和斯洛伐克口腔颌面外科的志愿研究人员和临床医生使用。:迄今为止,来自八个颌面单位的十五位同事已加入该研究。已记录180例患者的数据。从流行病学角度对收集的数据进行了统计分析和评估。:作者认为基于云的多中心数据收集是一种有用的工具,它允许用户之间进行实时协作,便于快速数据录入和分析,从而极大地有助于拓宽我们对双膦酸盐相关颌骨坏死的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7073980/4cbb3b242745/jcm-09-00426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7073980/4cbb3b242745/jcm-09-00426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d36b/7073980/4cbb3b242745/jcm-09-00426-g001.jpg

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Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ).软组织病理生理学在双膦酸盐相关颌骨坏死(BRONJ)发生和维持中的作用。
Dent J (Basel). 2016 Oct 25;4(4):36. doi: 10.3390/dj4040036.
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Osteonecrosis of the jaws: a 14-year retrospective survey of hospital admissions.
颌骨骨坏死:14 年住院患者回顾性调查。
Aust Dent J. 2018 Jun;63(2):202-207. doi: 10.1111/adj.12603. Epub 2018 Mar 25.
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Clin Oral Investig. 2018 Mar;22(2):597-615. doi: 10.1007/s00784-017-2325-6. Epub 2018 Jan 13.
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