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双侧与左侧精索静脉曲张切除术对患有左侧临床型和右侧亚临床型精索静脉曲张的不育男性的疗效:一项对比研究

Efficacy of bilateral and left varicocelectomy in infertile men with left clinical and right subclinical varicoceles: a comparative study.

作者信息

Zheng Yi Qun, Gao Xin, Li Zhi Jian, Yu Yuan Long, Zhang Zhi Gang, Li Wei

机构信息

Department of Urology, Zhongshan Hospital, Sun Yat-Sen University, Zhongshan City, China.

出版信息

Urology. 2009 Jun;73(6):1236-40. doi: 10.1016/j.urology.2008.11.050. Epub 2009 Apr 15.

Abstract

OBJECTIVES

To determine whether it is necessary to perform bilateral varicocelectomy (BV) in infertile men with left clinical and right subclinical varicoceles by comparing the outcomes of BV with those of left varicocelectomy (LV) in these patients.

METHODS

A total of 104 infertile men with left clinical and right subclinical varicoceles were randomly divided into 2 groups: BV (n = 51) and LV (n = 53). Both BV and LV were performed using a retroperitoneal approach with ligation of the dilated internal spermatic veins. The sperm concentration, sperm motility, normal morphology, serum testosterone level, bilateral testicular volume, and spontaneous pregnancy rate were measured pre- and postoperatively. Statistical analysis was performed using analysis of variance and the chi(2) test, with significance determined by P < .05.

RESULTS

The patients in the 2 groups had comparable preoperative age, partner age, sperm concentration, sperm motility, normal morphology, left varicocele grade, serum testosterone level, and bilateral testicular volume (P > .05). Both BV and LV resulted in significant increases in sperm concentration, sperm motility, and normal morphology (P < .05). No significant changes in serum testosterone level or bilateral testicular volume were observed after varicocelectomy in the 2 groups (P > .05). No significant differences were found in the postoperative sperm concentration, sperm motility, normal morphology, bilateral testicular volume, serum testosterone level, and spontaneous pregnancy rate between the 2 groups (P > .05).

CONCLUSIONS

These findings suggest that no benefit is realized with BV compared with LV in infertile men with left clinical and right subclinical varicoceles.

摘要

目的

通过比较双侧精索静脉曲张切除术(BV)与左侧精索静脉曲张切除术(LV)在患有左侧临床型和右侧亚临床型精索静脉曲张的不育男性中的治疗效果,来确定对这些患者进行双侧精索静脉曲张切除术是否必要。

方法

总共104例患有左侧临床型和右侧亚临床型精索静脉曲张的不育男性被随机分为两组:BV组(n = 51)和LV组(n = 53)。BV和LV均采用腹膜后入路,结扎扩张的精索内静脉。术前和术后测量精子浓度、精子活力、正常形态、血清睾酮水平、双侧睾丸体积和自然妊娠率。采用方差分析和卡方检验进行统计分析,以P <.05确定显著性。

结果

两组患者在术前年龄、配偶年龄、精子浓度、精子活力、正常形态、左侧精索静脉曲张分级、血清睾酮水平和双侧睾丸体积方面具有可比性(P >.05)。BV和LV均导致精子浓度、精子活力和正常形态显著增加(P <.05)。两组精索静脉曲张切除术后血清睾酮水平和双侧睾丸体积均未观察到显著变化(P >.05)。两组术后精子浓度、精子活力、正常形态、双侧睾丸体积、血清睾酮水平和自然妊娠率之间均未发现显著差异(P >.05)。

结论

这些发现表明,对于患有左侧临床型和右侧亚临床型精索静脉曲张的不育男性,与LV相比,BV并无益处。

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