Elzanaty Saad, Johansen Claus
Department of Translational Medicine, Division of Urological Research, Skåne University Hospital, Lund University, Malmö, Sweden.
Department of Radiology, Ystad Hospital, Ystad, Sweden.
Curr Urol. 2017 Apr;10(1):45-49. doi: 10.1159/000447150. Epub 2017 Mar 30.
The results of reports on the association between varicocele repair and testosterone levels were conflicting. The aim of the present study is, therefore, to investigate the impact of varicocele repair on testosterone levels.
The study is based on 20 men who experienced microsurgical subinguinal varicoceles repair because of chronic dull scrotal pain. All hormonal profiles available in the clinical records were reviewed. Follow-up evaluation was done at 1 and 12 months after surgery. Men were classified into groups based on the preoperative testosterone levels: euogonadal (serum levels of testosterone > 12 nmol/l), hypogonadal men (serum levels of testosterone ≤ 12 nmol/l).
Microsurgical subinguinal varicocele repair was associated with a significant improvements of testosterone levels at 1 and 12 months after surgery as compared to the preoperative levels (13 nmol/l vs. 18 nmol/l, p = 0.03; 13 nmol/l vs. 15 nmol/l, p = 0.01). The same trend was seen in men who were classified as being hypogonadal (7.0 nmol/l vs. 15 nmol/l, p = 0.01; 7.0 nmol/l vs. 10 nmol/l, p = 0.02). No significant improvements in testosterone levels were observed in euogonadal men (p > 0.05).
Microsurgical subinguinal varicocele repair was associated with a significant improvements of testosterone levels in men with grade II-III lesions and low preoperative testosterone values.
关于精索静脉曲张修复与睾酮水平之间关联的报告结果相互矛盾。因此，本研究的目的是调查精索静脉曲张修复对睾酮水平的影响。
本研究基于20名因慢性阴囊钝痛而接受显微外科腹股沟下精索静脉曲张修复术的男性。回顾了临床记录中所有可用的激素谱。在术后1个月和12个月进行随访评估。根据术前睾酮水平将男性分为几组：性腺功能正常（血清睾酮水平>12 nmol/l）、性腺功能减退男性（血清睾酮水平≤12 nmol/l）。
与术前水平相比，显微外科腹股沟下精索静脉曲张修复术后1个月和12个月时睾酮水平有显著改善（13 nmol/l对18 nmol/l，p = 0.03；13 nmol/l对15 nmol/l，p = 0.01）。在被归类为性腺功能减退的男性中也观察到相同趋势（7.0 nmol/l对15 nmol/l，p = 0.01；7.0 nmol/l对10 nmol/l，p = 0.02）。性腺功能正常的男性睾酮水平未观察到显著改善（p>0.05）。
显微外科腹股沟下精索静脉曲张修复与II - III级病变且术前睾酮值低的男性睾酮水平显著改善有关。
