Cleary Margot P, Grossmann Michael E
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.
Endocrinology. 2009 Jun;150(6):2537-42. doi: 10.1210/en.2009-0070. Epub 2009 Apr 16.
There is now substantial evidence that overweight and/or obesity and/or weight gain are risk factors for the development of postmenopausal breast cancer. In addition, obesity and/or elevated body mass index at breast cancer diagnosis has a negative impact on prognosis for both premenopausal and postmenopausal women. Therefore, understanding the mechanism of how obesity affects the mammary tumorigenesis process is an important health issue. Elevated serum estrogen levels as well as enhanced local production of estrogen have been considered primary mediators of how increased body weight promotes breast cancer development in postmenopausal women. Here, we provide an overview of estrogen's relationship with both obesity and breast cancer as separate entities. Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered.
目前有大量证据表明，超重和/或肥胖和/或体重增加是绝经后乳腺癌发生的危险因素。此外，乳腺癌诊断时的肥胖和/或升高的体重指数对绝经前和绝经后女性的预后均有负面影响。因此，了解肥胖影响乳腺肿瘤发生过程的机制是一个重要的健康问题。血清雌激素水平升高以及局部雌激素生成增加被认为是体重增加促进绝经后女性乳腺癌发展的主要介质。在此，我们概述雌激素与肥胖和乳腺癌这两个独立实体之间的关系。引用了人类和相关临床前研究。此外，还考虑了可能参与这种关系的其他生长因子。
