老年人的肌肉减少性肥胖和身体能力:来自营养决定成功老龄化研究(NuAge)-魁北克纵向研究的数据。
Sarcopenic/obesity and physical capacity in older men and women: data from the Nutrition as a Determinant of Successful Aging (NuAge)-the Quebec longitudinal Study.
机构信息
Research Centre on Aging, Health and Social Services Centre, University Institute of Geriatrics of Sherbrooke, Sherbrooke, Québec, Canada.
出版信息
Obesity (Silver Spring). 2009 Nov;17(11):2082-8. doi: 10.1038/oby.2009.109. Epub 2009 Apr 16.
Sarcopenia and obesity have been independently associated with physical capacity impairments. However, few studies have investigated the impact of sarcopenic/obesity on physical capacity in older individuals using objective measures of physical capacity and body composition. This study included 904 older individuals aged between 68 and 82 years old. Body composition (fat mass (FM) and lean body mass (LBM) by dual-energy X-ray absorptiometry (DXA)), physical capacity (timed up and go, chair stands, walking speed at normal and fastest pace, and one leg stand), sum of reported chronic conditions and physical activity level were measured. A global physical capacity score was then calculated giving a maximal score of 20. Finally, four groups were created within genders based on sarcopenia and obesity ((i) nonsarcopenic/nonobese; (ii) sarcopenic/nonobese; (iii) nonsarcopenic/obese; (iv) sarcopenic/obese). The four groups were significantly different for the sit-to-stand test and the one leg stand test (P < 0.05) and only for the one leg stand test in women (P < 0.05). In both genders results for the global physical capacity score revealed that both obese groups (sarcopenic and nonsarcopenic) were similar (P = 0.14 in men and P = 0.19 in women) and had a lower global physical capacity score compared to nonsarcopenic/nonobese individuals (P < 0.05). In addition, sarcopenic women displayed a higher score than both obese nonsarcopenic and obese sarcopenic groups (P < 0.01). Sarcopenic/obese men and women do not display lower physical capacity compared to nonsarcopenic/obese individuals in this cohort of well-functioning older men and women. Obesity per se appears to contribute more to lower physical capacity than sarcopenia.
肌少症和肥胖症与身体机能障碍独立相关。然而,很少有研究使用身体机能和身体成分的客观测量来调查肌少症/肥胖症对老年人身体机能的影响。本研究纳入了 904 名年龄在 68 至 82 岁之间的老年人。使用双能 X 射线吸收法(DXA)测量身体成分(脂肪量(FM)和瘦体重(LBM))、身体机能(起立-行走计时测试、椅子站立测试、正常和最快步速行走测试、单腿站立测试)、报告的慢性疾病总数和身体活动水平。然后计算出一个总的身体机能评分,最高得分为 20 分。最后,根据肌少症和肥胖症,在男女中分别创建了四个组((i) 非肌少症/非肥胖;(ii) 肌少症/非肥胖;(iii) 非肌少症/肥胖;(iv) 肌少症/肥胖)。在男女中,坐立-站立测试和单腿站立测试(P < 0.05)的四个组之间存在显著差异,而女性仅在单腿站立测试中(P < 0.05)存在差异。在两性中,总的身体机能评分的结果表明,肥胖组(肌少症和非肌少症)相似(男性 P = 0.14,女性 P = 0.19),与非肌少症/非肥胖个体相比,总的身体机能评分较低(P < 0.05)。此外,肌少症女性的评分高于肥胖非肌少症和肥胖肌少症组(P < 0.01)。在这个功能良好的老年男性和女性队列中,肌少症/肥胖症男性和女性的身体机能并不比非肌少症/肥胖症个体差。肥胖本身似乎比肌少症对较低的身体机能贡献更大。