18F-氟脱氧葡萄糖在子宫内膜和子宫肌层的生理摄取：与通过电影磁共振成像评估的子宫运动性的相关性

Physiological uptake of 18F-fluorodeoxyglucose in uterine endometrium and myometrium: correlation with uterine motility evaluated by cine magnetic resonance imaging.

作者信息

Kido A, Nakamoto Y, Nishizawa S, Yamamoto A, Fujimoto K, Okada H, Togashi K

机构信息

Hamamatsu Medical Imaging Center, Hamamatsu Medical Photonics Foundation, Hamakita City, Shizuoka, Japan.

出版信息

Acta Radiol. 2009 May;50(4):455-61. doi: 10.1080/02841850902839692.

DOI:10.1080/02841850902839692

PMID:19373569

Abstract

BACKGROUND

Accumulation of (18)F-fluorodeoxyglucose ((18)F-FDG) in the uterine endometrium and uterine motility are dependent on menstrual cycle. However, the relationship between them remains unknown.

PURPOSE

To investigate the relationship between radiometabolic activity of (18)F-FDG in the uterus and uterine motility observed by cine magnetic resonance imaging (MRI).

MATERIAL AND METHODS

The study population consisted of 65 healthy, fertile women, selected from 229 women who underwent positron emission tomography (PET), computed tomography (CT), and MRI for cancer screening at our facility. They were divided into three groups according to their menstrual cycle phases: menstrual, follicular-periovulatory, and luteal. Regions of interest (ROIs) were placed over the endometrium and myometrium to calculate the standardized uptake value (SUV). Uterine peristalsis and contraction shown by cine MR imaging were evaluated visually, and the correlation between FDG uptake and uterine movements was assessed.

RESULTS

After excluding nine patients due to inadequate images, 56 patients (19 follicular-periovulatory, 27 luteal, and 10 menstrual) were analyzed. FDG uptake of the endometrium, frequency of peristalsis, and the presence of sustained contraction varied according to the menstruation cycle, with a tendency toward greater uptake in the menstrual phase, but there was little relationship between the frequency of uterine peristalsis and FDG accumulation in the uterus. Significantly higher FDG accumulation in the endometrium was observed in patients with sustained contractions (3.32+/-1.47) than in those without contractions (2.45+/-0.66).

CONCLUSION

Our preliminary data suggest that FDG accumulation in the endometrium tends to be higher in patients with uterine contraction, although there was no significant correlation between uterine peristalsis and FDG uptake in the uterine myometrium or endometrium.

摘要

背景

子宫内膜中（18）F-氟脱氧葡萄糖（（18）F-FDG）的积聚以及子宫运动依赖于月经周期。然而，它们之间的关系尚不清楚。

目的

研究子宫中（18）F-FDG的放射性代谢活性与电影磁共振成像（MRI）观察到的子宫运动之间的关系。

材料与方法

研究对象包括65名健康、有生育能力的女性，她们是从在我们机构接受正电子发射断层扫描（PET）、计算机断层扫描（CT）和MRI癌症筛查的229名女性中挑选出来的。根据月经周期阶段将她们分为三组：月经期、卵泡期-排卵期和黄体期。在子宫内膜和子宫肌层上放置感兴趣区域（ROI）以计算标准化摄取值（SUV）。通过电影MRI成像观察子宫蠕动和收缩情况，并评估FDG摄取与子宫运动之间的相关性。

结果

在排除9例图像质量不佳的患者后，对56例患者（19例卵泡期-排卵期、27例黄体期和10例月经期）进行了分析。子宫内膜的FDG摄取、蠕动频率和持续收缩的情况随月经周期而变化，在月经期有摄取增加的趋势，但子宫蠕动频率与子宫内FDG积聚之间关系不大。在有持续收缩的患者中，子宫内膜中观察到的FDG积聚（3.32±1.47）明显高于无收缩的患者（2.45±0.66）。