生殖衰老、性类固醇与情绪障碍。
Reproductive aging, sex steroids, and mood disorders.
作者信息
Harsh Veronica, Meltzer-Brody Samantha, Rubinow David R, Schmidt Peter J
机构信息
Section on Behavioral Endocrinology, National Institute of Mental Health, Bethesda, MD 20892-1276, USA.
出版信息
Harv Rev Psychiatry. 2009;17(2):87-102. doi: 10.1080/10673220902891877.
Abstract
Epidemiologic studies have documented that the majority of women do not become depressed during the menopause transition. However, recent longitudinal studies suggest that in some women, the events related to the menopause transition could play a role in the onset of depression. In this article we review evidence suggesting a relationship between the menopause transition and depression. Additionally, we describe several findings that suggest a role of ovarian hormones in the onset of these depressions, including the clustering of episodes of depression during the stage of the menopause transition that is accompanied by estradiol withdrawal, and the therapeutic effects of short-term estradiol in depressed perimenopausal women. Finally, we discuss possible causes of affective disturbances during the menopause transition.
摘要
流行病学研究已证明，大多数女性在绝经过渡期间不会出现抑郁。然而，最近的纵向研究表明，在一些女性中，与绝经过渡相关的事件可能在抑郁症的发病中起作用。在本文中，我们回顾了表明绝经过渡与抑郁症之间存在关联的证据。此外，我们描述了一些研究结果，这些结果表明卵巢激素在这些抑郁症的发病中起作用，包括在伴有雌二醇撤退的绝经过渡阶段抑郁症发作的聚集，以及短期雌二醇对围绝经期抑郁症女性的治疗效果。最后，我们讨论了绝经过渡期间情感障碍的可能原因。
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