青春期应激源对雌性小鼠激素行为反应的持久影响。
Enduring influence of pubertal stressors on behavioral response to hormones in female mice.
机构信息
Neuroscience and Behavior Program and Center for Neuroendocrine Studies, University of Massachusetts-Amherst, MA 01003-9271, USA.
出版信息
Horm Behav. 2013 Jul;64(2):390-8. doi: 10.1016/j.yhbeh.2013.01.015.
Abstract
This article is part of a Special Issue "Puberty and Adolescence". The pubertal period is a time of change in an animal's response to stress, and it is a second period of sexual differentiation of the brain. Recently, it was discovered that particular stressors during the prolonged pubertal period of female mice result in enduring changes in behavioral responsiveness of the brain to estradiol and progesterone. Depending on the behavior, pubertal immune challenge or shipping from suppliers may decrease, eliminate, or even reverse the effects of estradiol. Pubertal immune challenge results in changes in the number of estrogen receptor-immunoreactive cells in key brain areas suggesting a cellular mechanism for this remodeling of the brain's response to hormones. A hypothesis is put forward that predicts that particular adverse experiences in girls may cause long-term alterations in the brain's response to estradiol and/or progesterone via activation of the immune system. This could lead to mood disorders or altered response to any behavior influenced by estradiol in humans.
摘要
本文是“青春期”特刊的一部分。青春期是动物对应激反应发生变化的时期，也是大脑第二次性分化的时期。最近发现，雌性小鼠青春期延长期间的特定应激源会导致大脑对雌二醇和孕酮的反应出现持久变化。根据行为的不同，青春期免疫挑战或从供应商处运输可能会降低、消除甚至逆转雌二醇的作用。青春期免疫挑战导致关键大脑区域中雌激素受体免疫反应细胞的数量发生变化，这表明了大脑对激素反应重塑的细胞机制。提出了一个假设，即女孩的某些不良经历可能通过激活免疫系统，导致大脑对雌二醇和/或孕酮的反应发生长期改变。这可能导致情绪障碍或改变人类受雌二醇影响的任何行为的反应。
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