Sadeq Adel, Baraka Mohamed A, Hamrouni Amar, Elnour Asim Ahmed
PhD, MSc. Assistant Professor, Program of Clinical Pharmacy, College of Pharmacy, Al Ain University, Al Ain-UAE, United Arab Emirates.
PhD, MSc. Assistant professor, Clinical Pharmacy department, College of Pharmacy, Al Ain University, Al Ain campus, United Arab Emirates, Assistant professor, Clinical Pharmacy department, College of Pharmacy, Al-Azhar University, Cairo, Egypt. mohamed.
Pharm Pract (Granada). 2022 Jul-Sep;20(3):2682. doi: 10.18549/PharmPract.2022.3.2682. Epub 2022 Jun 22.
There is a paucity of studies describing the risk factors for developing ischemic stroke in our region.
The objective of the current study was to delineate the potential risk factors for the development of ischemic stroke.
We have conducted a retrospective cohort hospitalbased study that has enrolled 231 subjects. The subjects have had presented to the emergency department in a tertiary hospital in the United Arab Emirates. Subjects were diagnosed with ischemic stroke within 24 hours of presentation.
The main outcome measure was the development of ischemic stroke during an indexed hospital visit.
The mean age was 47.5 ±3.2 with a higher preponderance of males over females (60.9%) and 48.1% were ≥ 65 years. The final logistic regression model for the development of ischemic stroke contains seven variables. In descending order, the seven predictive risk factors for the development of ischemic stroke were: hypertension (OR 6.1, CI 2.4-9.5; P = 0.029), coronary artery disease (OR 4.2, 3.7-9.1; P = 0.038), low physical activity (OR 4.2, CI 2.1-9.1; P = 0.035), history of previous stroke (OR 4.1, 1.4-3.4; P = 0.033), atrial fibrillation (OR 3.2, CI 2.6-8.2; P = 0.017), family history of stroke (OR 3.1, 1.3-6.9; P = 0.042) and diabetes mellitus (OR 2.7, CI 1.25-6.1; P = 0.035). The specificity of the model was 58.1%; the sensitivity was 86.1%, and the overall accuracy was 75.7%.
It is prudent to control modifiable risk factors for the development of strokes such as hypertension, diabetes, atrial fibrillation, coronary artery disease, and low physical activity.
在我们这个地区，描述缺血性中风发病风险因素的研究很少。
本研究的目的是确定缺血性中风发病的潜在风险因素。
我们进行了一项基于医院的回顾性队列研究，纳入了231名受试者。这些受试者曾到阿拉伯联合酋长国一家三级医院的急诊科就诊。受试者在就诊后24小时内被诊断为缺血性中风。
主要观察指标是在索引医院就诊期间缺血性中风的发生情况。
平均年龄为47.5±3.2岁，男性比女性占比更高（60.9%），48.1%的人年龄≥65岁。缺血性中风发病的最终逻辑回归模型包含七个变量。按降序排列，缺血性中风发病的七个预测风险因素为：高血压（比值比6.1，可信区间2.4 - 9.5；P = 0.029）、冠状动脉疾病（比值比4.2，3.7 - 9.1；P = 0.038）、低体力活动（比值比4.2，可信区间2.1 - 9.1；P = 0.035）、既往中风史（比值比4.1，1.4 - 3.4；P = 0.033）、心房颤动（比值比3.2，可信区间2.6 - 8.2；P = 0.017）、中风家族史（比值比3.1，1.3 - 6.9；P = 0.042）和糖尿病（比值比2.7，可信区间1.25 - 6.1；P = 0.035）。该模型的特异性为58.1%；敏感性为86.1%，总体准确率为75.7%。
控制中风发病的可改变风险因素如高血压、糖尿病、心房颤动、冠状动脉疾病和低体力活动是明智的。
