Jack Kevin S, Velayudhan Shiny, Luckman Paul, Trau Matt, Grøndahl Lisbeth, Cooper-White Justin
Centre for Nanotechnology and Biomaterials (Level 4E), The University of Queensland, St. Lucia, Qld 4072, Australia.
Acta Biomater. 2009 Sep;5(7):2657-67. doi: 10.1016/j.actbio.2009.03.017. Epub 2009 Mar 24.
This study reports the fabrication and characterization of nano-sized hydroxyapatite (HA)/poly(hydroxyabutyrate-co-hydroxyvalerate) (PHBV) polymer composite scaffolds with high porosity and controlled pore architectures. These scaffolds were prepared using a modified thermally induced phase-separation technique. This investigation focuses on the effect of fabrication conditions on the overall pore architecture of the scaffolds and the dispersion of HA nanocrystals within the composite scaffolds. The morphologies, mechanical properties and in vitro bioactivity of the composite scaffolds were investigated. It was noted that the pore architectures could be manipulated by varying phase-separation parameters. The HA particles were dispersed in the pore walls of the scaffolds and were well bonded to the polymer. The introduction of HA greatly increased the stiffness and strength, and improved the in vitro bioactivity of the scaffolds. The results suggest these newly developed nano-HA/PHBV composite scaffolds may serve as an effective three-dimensional substrate in bone tissue engineering.
本研究报告了具有高孔隙率和可控孔结构的纳米级羟基磷灰石（HA）/聚（羟基丁酸酯-共-羟基戊酸酯）（PHBV）聚合物复合支架的制备与表征。这些支架采用改进的热致相分离技术制备。本研究聚焦于制备条件对支架整体孔结构以及HA纳米晶体在复合支架内分散情况的影响。对复合支架的形态、力学性能和体外生物活性进行了研究。结果表明，通过改变相分离参数可以控制孔结构。HA颗粒分散在支架的孔壁中，并与聚合物良好结合。HA的引入极大地提高了支架的刚度和强度，并改善了其体外生物活性。结果表明，这些新开发的纳米HA/PHBV复合支架可作为骨组织工程中有效的三维基质。
