Thompson George R, Cadena Jose, Patterson Thomas F
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Clin Chest Med. 2009 Jun;30(2):203-15, v. doi: 10.1016/j.ccm.2009.02.001.
This article is a comprehensive clinically focused review of currently available antifungals administered by way of the intravenous or inhalational route: amphotericin B and its lipid formulations, fluconazole, itraconazole, posaconazole, voriconazole, caspofungin, micafungin, anidulafungin, and flucytosine. Emphasis is placed on pharmacodynamics and kinetics, drug interactions, adverse events, and evidence for their use. Selected clinical trials demonstrating the efficacy of these agents are also reviewed.
本文是一篇全面的临床聚焦综述，内容涉及目前通过静脉或吸入途径给药的抗真菌药物：两性霉素B及其脂质制剂、氟康唑、伊曲康唑、泊沙康唑、伏立康唑、卡泊芬净、米卡芬净、阿尼芬净和氟胞嘧啶。重点在于药效学和药代动力学、药物相互作用、不良事件以及它们的使用证据。还对证明这些药物疗效的部分临床试验进行了综述。
