造血干细胞移植和实体器官移植中的真菌感染——聚焦曲霉病

Fungal infections in hematopoietic stem cell transplantation and solid-organ transplantation--focus on aspergillosis.

作者信息

Nucci Marcio, Anaissie Elias

机构信息

Mycology Laboratory, Department of Internal Medicine, University Hospital, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, Rio de Janeiro, Brazil.

出版信息

Clin Chest Med. 2009 Jun;30(2):295-306, vii. doi: 10.1016/j.ccm.2009.03.001.

DOI:10.1016/j.ccm.2009.03.001

PMID:19375636

Abstract

Invasive fungal infections (IFIs) represent a major complication in recipients of hematopoietic stem cell transplantation and solid-organ transplantation. The incidence of IFIs in transplant recipients has increased over the past 20 years, and these infections continue to be associated with high morbidity and mortality. This article reviews the important concepts guiding the management of IFIs in transplant recipients, including epidemiologic trends, new risk factors, and a timetable of infections, pathogens, therapy, and prevention of these infections. An emphasis is given to invasive aspergillosis.

摘要

侵袭性真菌感染（IFI）是造血干细胞移植和实体器官移植受者的主要并发症。在过去20年中，移植受者中IFI的发病率有所上升，这些感染仍然与高发病率和高死亡率相关。本文综述了指导移植受者IFI管理的重要概念，包括流行病学趋势、新的危险因素以及感染、病原体、治疗和预防这些感染的时间表。重点介绍了侵袭性曲霉病。