Townsend Liam, Martin-Loeches Ignacio
Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, D08 NHY1 Dublin, Ireland.
Department of Clinical Medicine, School of Medicine, Trinity College Dublin, D02 PN91 Dublin, Ireland.
Diagnostics (Basel). 2022 Nov 6;12(11):2712. doi: 10.3390/diagnostics12112712.
Invasive pulmonary aspergillosis (IPA) is a serious condition resulting in significant mortality and morbidity among patients in intensive care units (ICUs). There is a growing number of at-risk patients for this condition with the increasing use of immunosuppressive therapies. The diagnosis of IPA can be difficult in ICUs, and relies on integration of clinical, radiological, and microbiological features. In this review, we discuss patient populations at risk for IPA, as well as the diagnostic criteria employed. We review the fungal biomarkers used, as well as the challenges in distinguishing colonization with from invasive disease. We also address the growing concern of multidrug-resistant and review the new and novel therapeutics which are in development to combat this.
侵袭性肺曲霉病（IPA）是一种严重疾病，在重症监护病房（ICU）患者中可导致显著的死亡率和发病率。随着免疫抑制疗法使用的增加，患这种疾病的高危患者数量不断增多。在ICU中，IPA的诊断可能很困难，且依赖于临床、放射学和微生物学特征的综合判断。在本综述中，我们讨论了IPA的高危患者群体以及所采用的诊断标准。我们回顾了所使用的真菌生物标志物，以及区分定植与侵袭性疾病的挑战。我们还讨论了对多重耐药性日益增加的关注，并回顾了正在研发的用于对抗这一情况的新型治疗方法。
