Zubovskaia Anna, Vazquez Jose A
Division of Infectious Diseases, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
J Fungi (Basel). 2025 Jan 17;11(1):70. doi: 10.3390/jof11010070.
Invasive aspergillosis (IA) is a fungal infection, which has traditionally been associated with neutropenia and immunosuppressive therapies. Our understanding of invasive aspergillosis has been evolving and, in the past few decades, IA among ICU patients has been recognized as a common infection and has become more widely recognized. The diagnosis and management of invasive aspergillosis in the ICU is particularly challenging, due to the unstable clinical condition of the patients, lack of diagnostic markers, increased risk of further clinical deterioration, multiple comorbidities, and a need for early assessment and treatment. In this article, we will discuss the challenges and pitfalls of the diagnosis and management of invasive aspergillosis in an ICU setting, along with a review of the current literature that is pertinent and specific to this population.
侵袭性曲霉病(IA)是一种真菌感染,传统上与中性粒细胞减少症和免疫抑制治疗有关。我们对侵袭性曲霉病的认识一直在不断发展,在过去几十年中,ICU患者中的IA已被公认为一种常见感染,并且得到了更广泛的认识。由于患者临床状况不稳定、缺乏诊断标志物、进一步临床恶化风险增加、多种合并症以及需要早期评估和治疗,ICU中侵袭性曲霉病的诊断和管理尤其具有挑战性。在本文中,我们将讨论ICU环境中侵袭性曲霉病诊断和管理的挑战与陷阱,并回顾与该人群相关的当前文献。