Wheat L Joseph
MiraBella Technologies and MiraVista Diagnostics, Indianapolis, IN 46241, USA.
Clin Chest Med. 2009 Jun;30(2):367-77, viii. doi: 10.1016/j.ccm.2009.02.012.
Detection of galactomannan antigen in serum or bronchoalveolar lavage fluid is useful for diagnosis of invasive aspergillosis, but the current serologic tests are not useful. (1-->3)-beta-D-glucan can be detected in the serum of patients who have aspergillosis, candidiasis, and a few other mold infections, but false-positive results limit its reliability for diagnosis. None of these methods is useful for diagnosis of zygomycosis and certain other less common mold infections. This article focuses on the detection of antigen and beta-D-glucan for diagnosis of invasive aspergillosis and candidiasis.
检测血清或支气管肺泡灌洗液中的半乳甘露聚糖抗原有助于侵袭性曲霉病的诊断，但目前的血清学检测方法并无帮助。（1→3）-β-D-葡聚糖可在患有曲霉病、念珠菌病及其他一些霉菌感染的患者血清中检测到，但假阳性结果限制了其诊断的可靠性。这些方法均无助于接合菌病及某些其他较罕见霉菌感染的诊断。本文重点介绍用于侵袭性曲霉病和念珠菌病诊断的抗原及β-D-葡聚糖检测。
