溶组织内阿米巴半乳糖凝集素在依赖黏附的哺乳动物细胞杀伤中的作用。
Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells.
作者信息
Saffer L D, Petri W A
机构信息
Department of Medicine, University of Virginia Medical Center, Charlottesville 22908.
出版信息
Infect Immun. 1991 Dec;59(12):4681-3. doi: 10.1128/iai.59.12.4681-4683.1991.
Abstract
Entamoeba histolytica extracellular killing of host cells is contact dependent. Adherence to human colonic epithelial cells and mucins is mediated by a galactose-specific lectin. The effect on cytotoxicity of a panel of monoclonal antibodies (MAb) directed against the galactose lectin was tested. As expected, those MAb which inhibited adherence also decreased cytotoxicity. However, one antilectin MAb blocked cytotoxicity after adherence had occurred, indicating that the lectin has a role in cell killing that is distinct from its adherence function.
摘要
溶组织内阿米巴对宿主细胞的胞外杀伤是接触依赖性的。其对人结肠上皮细胞和黏蛋白的黏附由一种半乳糖特异性凝集素介导。测试了一组针对半乳糖凝集素的单克隆抗体（MAb）对细胞毒性的影响。正如预期的那样，那些抑制黏附的MAb也降低了细胞毒性。然而，一种抗凝集素MAb在黏附发生后阻断了细胞毒性，这表明凝集素在细胞杀伤中具有与其黏附功能不同的作用。
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