Heine W
Universität Rostock, Medizinische Fakultät, Kinderklinik und Poliklinik, BRD.
Infusionstherapie. 1991 Aug;18(4):160-4.
Application of carbohydrates in pediatric infusion therapy has recently been limited to glucose and xylitol. Fructose and sorbitol, which formerly had been used widely as energy sources in parenteral nutrition, have meanwhile been banned in order to prevent fatal complications in patients with undiscovered hereditary disturbances in fructose metabolism. The aim of this review is to focus the attention on potential side effects and limitations of glucose administration in pediatric infusion therapy. With special regard to total parenteral nutrition in preterm infants, sufficient glucose conversion to N-acetylneuraminic acid and other carbohydrate building blocks of glycoproteins and gangliosides is to be placed in question. This might have consequences for normal brain development and can be considered a challenge for future research work in this field.
碳水化合物在儿科输液治疗中的应用近来仅限于葡萄糖和木糖醇。果糖和山梨醇曾作为肠外营养中的能量来源被广泛使用，但同时已被禁用，以防止未被发现的果糖代谢遗传性紊乱患者出现致命并发症。本综述的目的是将注意力集中在儿科输液治疗中葡萄糖给药的潜在副作用和局限性上。特别是对于早产儿的全肠外营养，葡萄糖向N-乙酰神经氨酸以及糖蛋白和神经节苷脂的其他碳水化合物组成部分的充分转化值得怀疑。这可能会对正常脑发育产生影响，并可被视为该领域未来研究工作的一项挑战。
