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在没有现场心胸外科支持的机构中,对急性左主干冠状动脉闭塞继发的急性心肌梗死进行直接经皮冠状动脉介入治疗。

Primary percutaneous coronary intervention for acute myocardial infarction secondary to acute left main coronary occlusion in an institution without on-site cardiothoracic surgical support.

作者信息

Chia Pow-Li, Khoo Brian-Chung-Hoe, Ng Chee-Keong, Lim Jimmy-Tien-Wei

机构信息

Tan Tock Seng Hospital, Department of Cardiology, Singapore.

出版信息

EuroIntervention. 2009 Mar;4(5):617-9. doi: 10.4244/eijv4i5a103.

DOI:10.4244/eijv4i5a103
PMID:19378682
Abstract

AIMS

There is no consensus on the optimal management of acute myocardial infarction due to acute left main coronary occlusion (LMCO). We evaluated the feasibility of primary percutaneous coronary intervention (PCI) for acute LMCO in an institution without on-site cardiothoracic surgical (CTS) support.

METHODS AND RESULTS

We retrospectively identified 20 patients, median age 67 years (range 38 to 81). Sixteen patients presented with cardiogenic shock. All patients required intra-aortic balloon pump counterpulsation and inotropic support. Sixteen patients underwent stenting and four had balloon angioplasty only. Thrombolysis In Myocardial Infarction 3 flow was restored in 13 patients. Post-PCI, six patients were transferred to a tertiary institution for further care: three underwent extracorporeal membrane oxygenation (ECMO), one underwent both ECMO and coronary artery bypass grafting (CABG), one died before ECMO initiation and one stabilised without further intervention. Thirteen patients died in-hospital. There was one subsequent death out of the seven hospital survivors, with median follow-up 390 days (range 60 to 660 days). There was a trend towards survival with a shorter door-to-balloon time (p = 0.07).

CONCLUSIONS

Primary PCI may be a feasible initial revascularisation strategy for acute LMCO in centres without on-site CTS support.

摘要

目的

对于急性左主干冠状动脉闭塞(LMCO)所致急性心肌梗死的最佳治疗方法,目前尚无共识。我们评估了在没有现场心胸外科(CTS)支持的机构中,对急性LMCO进行直接经皮冠状动脉介入治疗(PCI)的可行性。

方法与结果

我们回顾性确定了20例患者,中位年龄67岁(范围38至81岁)。16例患者出现心源性休克。所有患者均需要主动脉内球囊反搏和正性肌力支持。16例患者接受了支架置入术,4例仅接受了球囊血管成形术。13例患者心肌梗死溶栓3级血流恢复。PCI术后,6例患者被转至三级医疗机构接受进一步治疗:3例接受体外膜肺氧合(ECMO),1例接受ECMO和冠状动脉旁路移植术(CABG),1例在启动ECMO前死亡,1例病情稳定无需进一步干预。13例患者在住院期间死亡。7例住院幸存者中有1例随后死亡,中位随访时间390天(范围60至660天)。门球时间较短者有生存趋势(p = 0.07)。

结论

在没有现场CTS支持的中心,直接PCI可能是急性LMCO可行的初始血运重建策略。

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