Ohmiya Hirohisa, Moriya Toshimitsu, Sawamura Masaya
Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Org Lett. 2009 May 21;11(10):2145-7. doi: 10.1021/ol9007712.
The Cu-Xantphos system [Cu(O-t-Bu)-Xantphos, 10-15 mol %] catalyzes the intramolecular hydroamination of unactivated terminal alkenes bearing an unprotected aminoalkyl substituent in alcoholic solvents, giving pyrrolidine and piperidine derivatives in excellent yields. This system is applicable to both primary and secondary amines and tolerates a variety of functional groups.
铜-双齿膦配体体系[Cu(O-t-Bu)-双齿膦配体,10 - 15摩尔%]在醇类溶剂中催化带有未保护氨基烷基取代基的未活化末端烯烃的分子内氢胺化反应,以优异的产率得到吡咯烷和哌啶衍生物。该体系适用于伯胺和仲胺,并且能耐受多种官能团。