Pahadi Nirmal K, Tunge Jon A
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS, 66045-7582.
Synlett. 2009 Dec 1;19:3135-3138. doi: 10.1055/s-0029-1218293.
This manuscript details the development of a palladium-catalyzed hydroamination of vinyl ethers. It is proposed that palladium catalyzes the hydroamination via Bronsted base catalysis, where palladium is protonated by the relatively acidic sulfonamide to generate a palladium hydride as well as the active anionic sulfonamide nucleophile. Thus, this process is distinct from known palladium-catalyzed hydroaminations of styrene derivatives that utilize less acidic amines.
本手稿详细介绍了钯催化乙烯基醚的氢胺化反应的发展情况。有人提出，钯通过布朗斯特碱催化氢胺化反应，其中钯被相对酸性的磺酰胺质子化，生成氢化钯以及活性阴离子磺酰胺亲核试剂。因此，该过程不同于已知的利用酸性较弱的胺进行的钯催化苯乙烯衍生物的氢胺化反应。
