有机光氧化还原体系催化烯烃反 Markovnikov 氢胺化反应。
Anti-Markovnikov hydroamination of alkenes catalyzed by an organic photoredox system.
机构信息
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
出版信息
J Am Chem Soc. 2013 Jul 3;135(26):9588-91. doi: 10.1021/ja4031616. Epub 2013 Jun 19.
Abstract
Herein we report a metal-free method for the direct anti-Markovnikov hydroamination of unsaturated amines. Irradiation of the amine substrates with visible light in the presence of catalytic quantities of easily synthesized 9-mesityl-10-methylacridinium tetrafluoroborate and thiophenol as a hydrogen-atom donor furnished the nitrogen-containing heterocycles with complete regiocontrol. Two examples of intermolecular anti-Markovnikov alkene hydroamination are also disclosed.
摘要
在此，我们报告了一种不饱和胺的无金属直接反马氏加成氨氢化方法。在可见光照射下，在容易合成的 9-均三甲苯基-10-甲基吖啶四氟硼酸盐和作为氢原子供体的噻酚存在下，对胺底物进行辐照，以完全区域控制的方式得到含氮杂环。还公开了两个反马氏加成烯烃氨氢化的分子间实例。
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