Recouso R C, Stocco dos Santos R C, Freitas R, Santos R C, de Freitas A C, Brunner O, Beçak W, Lindsey C J
Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
Vet Comp Oncol. 2003 Mar;1(1):22-9. doi: 10.1046/j.1476-5829.2003.00006.x.
Ingestion of bracken fern (Pteridium aquilinum v. arachnoideum) is associated with digestive tract cancer in different regions of Japan, Venezuela and Brazil. In view of reports that dietary bracken fern causes chromosomal instability in cattle, the clastogenic effect of bracken fern was investigated, in a preliminary study, in peripheral lymphocytes obtained from habitual consumers and a control group of non-consumers, which were carefully investigated about cancer history or family cancer history, negative in both cases, using protocols comparable to those previously described in studies in cattle raised on bracken pastures. Cytogenetic analysis showed significant increased levels of chromosomal abnormalities, such as chromatid breaks, in cultured peripheral lymphocytes of the consumer group. There was no correlation with subjects, gender, smoking habits or alcohol consumption, and the only correlation was with prolonged exposure to dietary bracken.
在日本、委内瑞拉和巴西的不同地区,摄入蕨菜(Pteridium aquilinum v. arachnoideum)与消化道癌症有关。鉴于有报道称食用蕨菜会导致牛的染色体不稳定,在一项初步研究中,对习惯食用蕨菜者和非食用蕨菜的对照组(仔细调查了癌症病史或家族癌症病史,两者均为阴性)外周血淋巴细胞中蕨菜的致断裂效应进行了研究,所使用的方案与之前在蕨菜牧场饲养的牛的研究中所描述的方案类似。细胞遗传学分析显示,食用蕨菜者组培养的外周血淋巴细胞中染色体异常水平显著增加,如染色单体断裂。这与受试者、性别、吸烟习惯或饮酒量无关,唯一的关联是长期食用蕨菜。