泛素化——细菌效应蛋白的搭便车之旅。
Ubiquitination - a bacterial effector's ticket to ride.
作者信息
Thomas Mair, Holden David W
机构信息
Department of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.
出版信息
Cell Host Microbe. 2009 Apr 23;5(4):309-11. doi: 10.1016/j.chom.2009.03.010.
PMID:19380107
Abstract
Ubiquitination has many important cellular functions, including regulation of plasma membrane endocytosis. In their recent article in Cell, Patel et al. (2009) show that the activity of the multifunctional Salmonella virulence protein SopB is controlled by ubiquitin-dependent delivery from the plasma membrane to the Salmonella-containing vacuole.
摘要
泛素化具有许多重要的细胞功能，包括调节质膜内吞作用。在他们最近发表于《细胞》杂志的文章中，帕特尔等人（2009年）表明，多功能沙门氏菌毒力蛋白SopB的活性受泛素依赖性从质膜转运至含沙门氏菌液泡的调控。
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