Matsushita Hidenobu, Honda Ichiro, Kato Nobuyuki, Tsuboi Kenji, Okochi Osamu, Kobayashi Daisuke, Hattori Masashi, Takami Yuko, Hashimoto Ryouji, Takeda Shigeomi, Mizuno Akira
Department of Surgery, Tosei General Hospital.
Gan To Kagaku Ryoho. 2009 Apr;36(4):647-50.
We report a patient with advanced gastric cancer responding remarkably to neoadjuvant combination chemotherapy consisting of paclitaxel and S-1. The patient was a 65-year-old female who had large type 2 advanced gastric cancer with severe lymph node metastasis(cT3, cN3, cH0, cP0, cM0, cStage IV), treated with paclitaxel/S-1 as neoadjuvant chemotherapy. After the second course, according to UGI, gastroscope and CT findings, a significant tumor reduction was obtained. Distal gastrectomy with D2 nodal dissection were performed. The histological diagnosis was pT1, pN1, pStage IB. The histological effect of main tumor was judged to be Grade 2. The patient has now been in good health without a recurrence for 10 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/ S-1 is a potential regimen for advanced gastric cancer.
我们报告了一名晚期胃癌患者，其对由紫杉醇和S-1组成的新辅助联合化疗有显著反应。该患者为一名65岁女性，患有伴有严重淋巴结转移的2型晚期胃癌（cT3、cN3、cH0、cP0、cM0、cStage IV），接受紫杉醇/S-1作为新辅助化疗。在第二个疗程后，根据上消化道造影、胃镜和CT检查结果，肿瘤显著缩小。进行了远端胃切除术加D2淋巴结清扫术。组织学诊断为pT1、pN1、pStage IB。主要肿瘤的组织学疗效判定为2级。该患者术后10个月身体健康，无复发。本病例表明，紫杉醇/S-1新辅助化疗是晚期胃癌的一种潜在治疗方案。
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