Akazawa Naoya, Taguchi Koichi, Imai Atsushi, Kikuchi Hironori, Minato Masaoki, Iwaki Hiroyuki
Department of Surgery, Sunagawa City Medical Center.
Gan To Kagaku Ryoho. 2010 Jul;37(7):1365-7.
A 71-year-old man suffering from epigastric discomfort and dizziness was admitted to our hospital and diagnosed with advanced gastric cancer with bulky lymph node metastases and liver metastasis. We thought a complete resection would be difficult, so he was treated with neo-adjuvant immunochemotherapy in combination with S-1 80 mg/m2 (2 weeks administration and 2-week rest), paclitaxel (PTX) 50 mg/m2 (day 1, 8, 15) and Lentinan (LNT) 2 mg/body (day 1, 8, 15). After 5 courses of this treatment, swollen lymph nodes decreased in size and the metastatic liver tumor disappeared. Total gastrectomy with lymph node dissection was performed. The histological diagnosis was pT2 pN0, Stage I B. Histological effects of primary tumor and lymphnodes were judged to be grade 2 and grade 3, respectively. We considered that the combination of S-1, PTX and LNT can be effective and safe for advanced gastric cancer.
一名71岁男性因上腹部不适和头晕入住我院，被诊断为晚期胃癌伴巨大淋巴结转移和肝转移。我们认为完整切除困难，因此对他进行了新辅助免疫化疗，联合S-1 80 mg/m²（给药2周，休息2周）、紫杉醇（PTX）50 mg/m²（第1、8、15天）和香菇多糖（LNT）2 mg/体（第1、8、15天）。经过5个疗程的这种治疗后，肿大的淋巴结缩小，肝转移瘤消失。遂行全胃切除加淋巴结清扫术。组织学诊断为pT2 pN0，ⅠB期。原发肿瘤和淋巴结的组织学疗效分别判定为2级和3级。我们认为S-1、PTX和LNT联合应用对晚期胃癌有效且安全。
