肾移植后的巨细胞病毒和BK多瘤病毒感染

[Cytomegalovirus and BK polyomavirus infection after renal transplantation].

作者信息

De Paolis P, Gervasio E, Tedesco M, Favaro' A, Iappelli M, Di Giulio S

机构信息

U.O.C. Nefrologia, Dialisi e Trapianto, Polo Ospedaliero Interaziendale Trapianti, A.O. S. Camillo-Forlanini, INMI L. Spallanzani, Roma 00151, Italy.

出版信息

G Ital Nefrol. 2009 Mar-Apr;26 Suppl 45:S46-53.

PMID:19382094

Abstract

Cytomegalovirus (CMV) and BK polyomavirus (BKV) infections have been described in a high percentage of renal transplant patients and are known to cause various complications in renal transplantation. They are closely related to immunosuppressive therapy and implicated in the progression of graft failure. This review focuses on the clinical aspects of CMV and BKV infection after renal transplantation, optimal monitoring, and recent preventive measures and interventions to improve graft function and recipient survival.

摘要

巨细胞病毒（CMV）和BK多瘤病毒（BKV）感染在很大比例的肾移植患者中都有报道，并且已知它们会在肾移植中引发各种并发症。它们与免疫抑制治疗密切相关，并与移植肾功能衰竭的进展有关。本综述重点关注肾移植后CMV和BKV感染的临床情况、最佳监测方法以及近期为改善移植肾功能和受者存活率而采取的预防措施和干预手段。