Division of Infectious Diseases, Georgetown University Hospital, Washington, DC 20007, USA.
Infect Dis Clin North Am. 2013 Jun;27(2):271-83. doi: 10.1016/j.idc.2013.02.002. Epub 2013 Apr 17.
Renal transplant recipients continue to have progressive kidney dysfunction and renal graft loss has been attributed to emerging opportunistic infections, specifically BK virus (BKV). BKV is postulated to be selected by the new potent immunosuppressive medications and to be an important factor in graft failure. The prevalence of BKV nephropathy (BKVN) is estimated to be 1% to 10% and renal allograft loss from BKVN has been estimated to occur in up to 50% of affected recipients. With the increasing recognition of BKV infection using PCR assays coupled with the immediate reduction in immunosuppression for BKVN, the incidence of graft failure secondary to BKVN may be decreasing.
肾移植受者的肾功能仍在进行性下降，肾移植物丢失归因于新出现的机会性感染，特别是 BK 病毒（BKV）。推测 BKV 是由新型强效免疫抑制剂选择而来，是移植物失功的一个重要因素。BKV 肾病（BKVN）的患病率估计为 1%至 10%，而 BKVN 导致的肾移植失败的发生率估计高达 50%。随着聚合酶链反应（PCR）检测对 BKV 感染的认识不断提高，以及对 BKVN 即刻减少免疫抑制，继发于 BKVN 的移植物失功的发生率可能正在下降。
