5-芳基-3-烷基磺酰基苯酚和5-芳基-3-芳基磺酰基苯酚文库的实用合成

Practical synthesis of 5-aryl-3-alkylsulfonyl-phenol and 5-aryl-3-arylsulfonyl-phenol libraries.

作者信息

Jeges Gyorgy, Nagy Tamas, Meszaros Tamas, Kovacs Jozsef, Dorman Gyorgy, Kowalczyk Agnieszka, Goodnow Robert A

机构信息

AMRI, Zahony u 7, 1031 Budapest, Hungary.

出版信息

J Comb Chem. 2009 Mar 9;11(2):327-34. doi: 10.1021/cc800172h.

DOI:10.1021/cc800172h

PMID:19206513

Abstract

A straightforward and cost-effective synthesis of 5-aryl-3-alkylsulfonyl-phenols by a sequential scaffold derivatization strategy has been developed. The procedure is suitable for parallel synthesis of small libraries around the biphenyl privileged core having an unusual 1,3,5-substitution pattern. The synthesis is exemplified by a pilot library of 30 compounds.

摘要

通过连续支架衍生化策略，已开发出一种简单且经济高效的合成5-芳基-3-烷基磺酰基苯酚的方法。该方法适用于围绕具有不寻常的1,3,5-取代模式的联苯特权核心平行合成小型文库。以一个包含30种化合物的先导文库为例说明了该合成方法。