水中微波辅助多组分反应合成异恶唑并[5,4 - b]吡啶

Synthesis of isoxazolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water.

作者信息

Tu Shu-Jiang, Zhang Xiao-Hong, Han Zheng-Guo, Cao Xu-Dong, Wu Shan-Shan, Yan Shu, Hao Wen-Juan, Zhang Ge, Ma Ning

机构信息

School of Chemistry and Chemical Engineering, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu 221116, PR China.

出版信息

J Comb Chem. 2009 May-Jun;11(3):428-32. doi: 10.1021/cc800212v.

DOI:10.1021/cc800212v

PMID:19364093

Abstract

A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.

摘要

在水中微波辐射下通过一锅串联反应得到了一系列新型多环稠合异恶唑并[5,4 - b]吡啶。该合成方案无需使用任何额外的试剂或催化剂，是一种绿色方法，使其适用于药物研发中的库合成。