L-色氨酸与小耳婴猴（加纳婴猴）自我伤害行为的相关性
L-tryptophan and correlates of self-injurious behavior in small-eared bushbabies (Otolemur garnettii).
作者信息
Watson Sheree L, McCoy John G, Fontenot M Babette, Hanbury David B, Ward Christopher P
机构信息
University of Southern Mississippi, Department of Psychology, Hattiesburg, Mississippi, USA.
出版信息
J Am Assoc Lab Anim Sci. 2009 Mar;48(2):185-91.
Self-injurious behavior (SIB) among captive primates is a recurring problem for those who manage such facilities. Its prevalence highlights the need for research evaluating the effectiveness of potential treatment approaches. In the present study, 4 wk of dietary supplementation with L-tryptophan (100 mg daily) was evaluated for the treatment of self-inflicted wounds in 22 small-eared bushbabies, a prosimian primate, with a history of SIB. The treatment significantly reduced stereotypy and was associated with a reduction in wound area and severity. In terms of physiologic measures, preexisting high levels of cortisol were reduced in bushbabies with SIB, whereas serotonin concentrations were increased after 4 wk of treatment. Results indicate that L-tryptophan as a dietary supplement may be a viable adjunct to standard husbandry procedures for animals exhibiting maladaptive behaviors such as stereotypy and SIB.
对于管理圈养灵长类动物设施的人来说，圈养灵长类动物的自伤行为（SIB）是一个反复出现的问题。其普遍性凸显了开展研究以评估潜在治疗方法有效性的必要性。在本研究中，对22只小耳婴猴（一种原猴灵长类动物，有自伤行为史）进行了为期4周的L-色氨酸饮食补充（每日100毫克），以治疗其自身造成的伤口。该治疗显著减少了刻板行为，并与伤口面积和严重程度的降低相关。在生理指标方面，有自伤行为的婴猴先前较高的皮质醇水平降低了，而在治疗4周后血清素浓度增加了。结果表明，L-色氨酸作为饮食补充剂，对于表现出如刻板行为和自伤行为等适应不良行为的动物而言，可能是标准饲养程序的一种可行辅助手段。
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