Lalonde Robert, Strazielle Catherine
Faculté de Médecine et de Pharmacie, Université de Rouen, Bâtiment de Recherche, 22 bld Gambetta, INSERM U614, IFRMP 23, Salle 1B10, 76183 , Rouen Cedex, France.
Neurochem Res. 2006 Jul;31(7):921-4. doi: 10.1007/s11064-006-9096-9. Epub 2006 Jun 29.
Ataxic Rora(sg) (staggerer) mouse mutants, containing a deletion of the Rora gene which encodes a retinoid-like nuclear receptor, were compared to non-ataxic controls for concentrations of 5-hydroxytryptamine (HT), its main metabolite (5-hydroxy-indole acetic acid, 5HIAA), and its precursor (tryptophan) in cerebellum, brainstem, and forebrain. In Rora(sg) cerebellum, 5HT concentrations increased relative to controls, while tryptophan concentrations decreased. 5HIAA concentrations increased in mutant cerebellum and brainstem, but the 5HIAA/5HT ratio declined only in cerebellum. These results indicate that 5HT turnover decreased in cerebellum of an ataxic mutant, perhaps indicative of presynaptic accumulation and compromised neurotransmission and susceptible to be modified by 5HT pharmacotherapy.
共济失调型Rora(sg)（蹒跚症）小鼠突变体缺失编码类视黄醇核受体的Rora基因，将其与非共济失调型对照小鼠比较，检测小脑、脑干和前脑中5-羟色胺（5-HT）、其主要代谢物（5-羟吲哚乙酸，5HIAA）及其前体（色氨酸）的浓度。在Rora(sg)小鼠的小脑中，5-HT浓度相对于对照小鼠升高，而色氨酸浓度降低。突变体小鼠的小脑和脑干中5HIAA浓度升高，但仅小脑的5HIAA/5-HT比值下降。这些结果表明，共济失调型突变体小鼠小脑中5-HT周转率降低，可能表明突触前积累、神经传递受损，且易受5-HT药物治疗的影响。
