Patel Rujul R
Department of Internal Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.
Cardiol Rev. 2009 May-Jun;17(3):132-5. doi: 10.1097/CRD.0b013e31819faab2.
Thiazolidinediones are oral antihyperglycemic drugs that have gained significant popularity for use in the treatment of type 2 diabetes mellitus. Their insulin sensitizing effects lead to better glycemic control, in addition to improvements in several cardiovascular parameters independent of blood glucose levels. The pleiotropic effects of thiazolidinediones have led to several cardiovascular outcome studies, many of which have shown promising data, but some of which bring about significant concern. Additionally, the propensity to cause weight gain, fluid retention, peripheral edema, and increased risk of heart failure hospitalizations continue to pose significant challenges for clinicians using these agents in patients with congestive heart failure.
噻唑烷二酮类是口服抗高血糖药物，在治疗2型糖尿病方面已获得广泛应用。除了改善一些与血糖水平无关的心血管参数外，它们的胰岛素增敏作用还能更好地控制血糖。噻唑烷二酮类的多效性作用引发了多项心血管结局研究，其中许多研究显示出有前景的数据，但也有一些研究引起了重大关注。此外，导致体重增加、液体潴留、外周水肿以及心力衰竭住院风险增加的倾向，继续给在充血性心力衰竭患者中使用这些药物的临床医生带来重大挑战。
