McCaughan Geoffrey W, Shackel Nicholas A, Bertolino Patrick, Bowen David G
AW Morrow Gastroenterology and Liver Centre, Centenary Institute, Royal Prince Alfred Hospital and Sydney University, Sydney, Australia.
Transplantation. 2009 Apr 27;87(8):1105-11. doi: 10.1097/TP.0b013e31819dfa83.
Hepatitis C virus (HCV)-related liver disease postliver transplantation is associated with an accelerated course in comparison with that observed in the nonimmunosuppressed individual. Outcomes in transplantation for this indication have, therefore, been a major area of clinical interest in the field of liver transplantation. The factors underlying the rapid progression of HCV-related liver disease posttransplantation are complex and multifactorial. Nevertheless, recent data indicate a range of parameters assessable early posttransplantation that may be useful in the prediction of outcome of transplantation for this condition. This overview, therefore, concentrates on the early events occurring postliver transplantation in the HCV-infected patient, and the implications of these recent observations for the pathogenesis of the various forms of HCV-related allograft injury.
与非免疫抑制个体相比，肝移植后丙型肝炎病毒（HCV）相关肝病病程进展更快。因此，针对这一适应症的肝移植结果一直是肝移植领域临床关注的重点。移植后HCV相关肝病快速进展的潜在因素复杂且具有多方面性。然而，近期数据表明，移植后早期可评估的一系列参数可能有助于预测针对这种情况的移植结果。因此，本综述重点关注HCV感染患者肝移植后的早期事件，以及这些最新观察结果对各种形式的HCV相关同种异体移植物损伤发病机制的影响。
