新斯的明和格隆溴铵对皮肤电传导作为疼痛测量指标的影响。
The effects of neostigmine and glycopyrrolate on skin conductance as a measure of pain.
机构信息
Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia.
出版信息
Eur J Anaesthesiol. 2009 Sep;26(9):777-81. doi: 10.1097/EJA.0b013e32832bb678.
BACKGROUND AND OBJECTIVE
The number of fluctuations in skin conductance per second has been shown to correlate with postoperative pain. In this context, the effects of cholinesterase inhibitors and anticholinergic drugs used for the reversal of muscle relaxants were investigated.
METHODS
Muscle relaxant effects were reversed in 30 patients with neostigmine and glycopyrrolate. No reversal agents were given to 30 controls. Patients' level of pain was quantified using a numeric rating scale (0-10) at several time points in the recovery room. The number of fluctuations in skin conductance per second was measured simultaneously.
RESULTS
The number of fluctuations in skin conductance per second was significantly higher in patients with no and severe pain in the control compared with the reversal group (no pain 0.19 vs. 0.12; severe pain 0.40 vs. 0.19). The number of fluctuations in skin conductance per second was less sensitive to identify time points with moderate/severe pain in the reversal group.
CONCLUSION
Skin conductance-based assessment of pain is affected by reversal agents.
背景与目的
皮肤电传导每秒的波动次数与术后疼痛相关。在这种情况下，研究了用于逆转肌肉松弛剂的胆碱酯酶抑制剂和抗胆碱能药物的作用。
方法
30 名患者使用新斯的明和格隆溴铵逆转肌肉松弛剂的作用。30 名对照患者未给予逆转剂。在恢复室的几个时间点，使用数字评分量表（0-10）对患者的疼痛程度进行量化。同时测量皮肤电传导每秒的波动次数。
结果
在无疼痛和严重疼痛的对照患者中，皮肤电传导每秒的波动次数明显高于逆转组（无疼痛 0.19 对 0.12；严重疼痛 0.40 对 0.19）。在逆转组中，皮肤电传导每秒的波动次数对识别中度/重度疼痛的时间点不太敏感。
结论
基于皮肤电导的疼痛评估受逆转剂的影响。
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