Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, Brazil.
Med Mycol. 2010 Feb;48(1):182-7. doi: 10.3109/13693780902893405.
The association of paracoccidioidomycosis with AIDS is apparently less frequent than expected. The authors present an unusual case of paracoccidioidomycosis in a 13-year-old female student which was later found to be the first opportunistic infection in the course of the patient's HIV-infection. The clinical presentation followed an accidental incised wound on the palmar region initially described as a 'sporotrichotic-chancre'. After good response under sulfamethoxazole-trimethoprin, the patient relapsed and presented an associated oral candidiasis. HIV-infection was documented and additional investigation showed CD4(+) T-cells=22/mm(3), CD8(+)=280 cell/mm(3) and viral load=4,043 log. This case report presents an uncommon dermatological-clinical picture in the youngest patient in which such association has been reported to date.
球孢子菌病与艾滋病的关联似乎比预期的要少。作者介绍了一例不常见的 13 岁女性学生的球孢子菌病病例，后来发现这是该患者 HIV 感染过程中的首例机会性感染。临床表现为手掌区域的意外切割伤，最初被描述为“孢子丝菌样下疳”。在磺胺甲恶唑-甲氧苄啶治疗后反应良好后，患者复发并出现口腔念珠菌病。HIV 感染得到证实，进一步检查显示 CD4(+) T 细胞=22/mm(3)，CD8(+)=280 细胞/mm(3)，病毒载量=4.043 log。本病例报告呈现了迄今为止在该年龄最小的患者中报告的一种不常见的皮肤科临床表现。
