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肝移植患者播散性球孢子菌病。

Disseminated paracoccidioidomycosis in a liver transplant patient.

机构信息

Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.

出版信息

An Bras Dermatol. 2021 May-Jun;96(3):346-348. doi: 10.1016/j.abd.2020.07.011. Epub 2021 Mar 15.

DOI:10.1016/j.abd.2020.07.011
PMID:33775484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8178573/
Abstract

Paracoccidioidomycosis is an endemic systemic mycosis caused by Paracoccidioides brasiliensis complex and P. lutzii. It is a rare disease in non-HIV-induced immunosuppressed individuals. In organ transplant recipients, it is more frequently associated with immunosuppression after kidney transplantation. In a liver transplant patient, only one case has been published in the literature to date. The present report comprises the case of a 47-year-old female patient with disseminated skin lesions associated with signs and symptoms of systemic involvement of paracoccidioidomycosis that manifested one year after liver transplantation and under an immunosuppression regimen with tacrolimus and mycophenolate mofetil.

摘要

巴西副球孢子菌病是一种由巴西副球孢子菌复合体和 P. lutzii 引起的地方性系统性真菌病。在非 HIV 诱导免疫抑制个体中，它是一种罕见疾病。在器官移植受者中，它更多地与肾移植后免疫抑制相关。在肝移植患者中，迄今为止，文献中仅报道过一例。本报告包含一例 47 岁女性患者的病例，该患者在肝移植一年后出现播散性皮肤损伤，并伴有系统性副球孢子菌病的全身受累的体征和症状，同时接受他克莫司和霉酚酸酯的免疫抑制治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/7ce4742dbcf7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/a850dc2ab03e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/6d5667e83594/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/2ba5cb1d5d8f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/7ce4742dbcf7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/a850dc2ab03e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/6d5667e83594/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/2ba5cb1d5d8f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd7/8178573/7ce4742dbcf7/gr4.jpg

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2
Ecology of Paracoccidioides brasiliensis, P. lutzii and related species: infection in armadillos, soil occurrence and mycological aspects.巴西副球孢子菌、卢氏副球孢子菌及相关菌种的生态学：犰狳感染、土壤中的存在情况及真菌学特征
Med Mycol. 2018 Nov 1;56(8):950-962. doi: 10.1093/mmy/myx142.
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Brazilian guidelines for the clinical management of paracoccidioidomycosis.
通过DEC205受体在体内靶向成熟树突状细胞中的P10肽：一种抗副球孢子菌病的新治疗策略。
J Fungi (Basel). 2023 May 10;9(5):548. doi: 10.3390/jof9050548.
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Diagnosis and Treatment of Pulmonary Coccidioidomycosis and Paracoccidioidomycosis.肺球孢子菌病和副球孢子菌病的诊断与治疗
J Fungi (Basel). 2023 Feb 7;9(2):218. doi: 10.3390/jof9020218.
巴西副球孢子菌病临床管理指南。
Rev Soc Bras Med Trop. 2017 Sep-Oct;50(5):715-740. doi: 10.1590/0037-8682-0230-2017. Epub 2017 Jul 12.
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Species boundaries in the human pathogen Paracoccidioides.人类病原体副球孢子菌的物种界限。
Fungal Genet Biol. 2017 Sep;106:9-25. doi: 10.1016/j.fgb.2017.05.007. Epub 2017 Jun 9.
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Paracoccidioidomycosis in a liver transplant recipient.肝移植受者的副球孢子菌病
Rev Soc Bras Med Trop. 2017 Jan-Feb;50(1):138-140. doi: 10.1590/0037-8682-0282-2016.
6
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Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12655. Epub 2017 Mar 6.
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