后他汀，一种由绿色产色链霉菌MH534-30F3产生的脯氨酰内肽酶新抑制剂。II. 结构测定与抑制活性。
Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. II. Structure determination and inhibitory activities.
作者信息
Nagai M, Ogawa K, Muraoka Y, Naganawa H, Aoyagi T, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1991 Sep;44(9):956-61. doi: 10.7164/antibiotics.44.956.
Poststatin, a new inhibitor of prolyl endopeptidase, has been isolated from the culture broth of Streptomyces viridochromogenes MH534-30F3. The structure of poststatin was defined as L-valyl-L-valyl-3-amino-2-oxovaleryl-D-leucyl-L-valine by analysis of spectral properties and chemical studies of poststatin and its derivatives. The alpha-keto group of postine in poststatin plays the most important role on the inhibitory mechanism.
抑肽菌素是从绿色产色链霉菌MH534 - 30F3的培养液中分离出的一种脯氨酰内肽酶新抑制剂。通过对抑肽菌素及其衍生物的光谱性质分析和化学研究，抑肽菌素的结构被确定为L-缬氨酰-L-缬氨酰-3-氨基-2-氧代戊酰基-D-亮氨酰-L-缬氨酸。抑肽菌素中抑肽氨酸的α-酮基在抑制机制中起最重要作用。
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