优司他汀A和B，新型脯氨酰内肽酶抑制剂。II. 物理化学性质及结构测定
Eurystatins A and B, new prolyl endopeptidase inhibitors. II. Physico-chemical properties and structure determination.
作者信息
Toda S, Kotake C, Tsuno T, Narita Y, Yamasaki T, Konishi M
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Oct;45(10):1580-6. doi: 10.7164/antibiotics.45.1580.
PMID:1473985
Abstract
The structures of eurystatins A and B, new prolyl endopeptidase inhibitors, have been elucidated by chemical degradation and spectral studies. They have in common a unique 13-membered cyclic peptide core composed of L-leucine, L-ornithine and (S)-3-amino-2-oxobutyric acid, and differ from each other in the alpha,beta-unsaturated fatty acid attached to the alpha-amino moiety of the ornithine.
摘要
新型脯氨酰内肽酶抑制剂优司他汀A和B的结构已通过化学降解和光谱研究得以阐明。它们具有共同的由L-亮氨酸、L-鸟氨酸和(S)-3-氨基-2-氧代丁酸组成的独特的13元环肽核心，且彼此的区别在于连接在鸟氨酸α-氨基部分的α,β-不饱和脂肪酸。
Zotero 插件