Stagg Charlotte J, Best Jonathan G, Stephenson Mary C, O'Shea Jacinta, Wylezinska Marzena, Kincses Z Tamas, Morris Peter G, Matthews Paul M, Johansen-Berg Heidi
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom.
J Neurosci. 2009 Apr 22;29(16):5202-6. doi: 10.1523/JNEUROSCI.4432-08.2009.
Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.
经颅直流电刺激（tDCS）可调节皮层兴奋性，且在人体研究中的应用日益频繁。在此，我们通过磁共振波谱（MRS）测量神经递质浓度的极性特异性变化，以探究其潜在的神经元机制。MRS提供的证据表明，兴奋性（阳极）tDCS会导致局部GABA减少，而抑制性（阴极）刺激会导致谷氨酸能神经元活动减少，同时GABA也高度相关地减少，这可能是由于这两种神经递质之间密切的生化关系所致。
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