O'Leary James D, Main Bevan S, Burns Mark P
Laboratory for Brain Injury and Dementia, Department of Neuroscience, Georgetown University Medical Centre, Washington, DC, United States.
Front Neurol. 2025 May 14;16:1560777. doi: 10.3389/fneur.2025.1560777. eCollection 2025.
Traumatic brain injury is a leading cause of death and a major risk factor for the development of both memory and motor disorders. To date, there are no proven interventions to improve patient outcome after neurotrauma. A promising avenue of treatment has emerged in the use of non-invasive therapies for recovery after brain injury. A number of non-invasive brain stimulation techniques have been developed, such as transcranial direct current stimulation, transcranial magnetic stimulation and vagus nerve stimulation, as well as low intensity ultrasound stimulation and photobiomodulation therapy. However, standardized treatment regimens have not been developed. There is a clear need to better understand the underlying mechanisms of non-invasive therapeutics on brain injury pathology so as to more effectively guide treatment strategy. Here we review the current literature of non-invasive therapies in preclinical neurotrauma and offer insight into the potential mechanism of action and novel targets for the treatment of traumatic brain injury.
创伤性脑损伤是死亡的主要原因，也是记忆和运动障碍发生的主要风险因素。迄今为止，尚无经证实的干预措施可改善神经创伤后的患者预后。在使用非侵入性疗法促进脑损伤后恢复方面，已出现一条有前景的治疗途径。已开发出多种非侵入性脑刺激技术，如经颅直流电刺激、经颅磁刺激和迷走神经刺激，以及低强度超声刺激和光生物调节疗法。然而，尚未制定标准化的治疗方案。显然需要更好地了解非侵入性治疗对脑损伤病理的潜在机制，以便更有效地指导治疗策略。在此，我们综述了临床前神经创伤中非侵入性疗法的当前文献，并深入探讨了创伤性脑损伤治疗的潜在作用机制和新靶点。
